POS1306 TREATMENT STRATEGIES IN CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS (CMRO) OR CHRONIC NON-BACTERIAL OSTEOMYELITIS (CNO): SYSTEMATIC REVIEW AND META-ANALYSIS

Background: Glucocorticoids (GC), bisphosphonates (BP), non-steroidal anti-inflammatory drugs (NSAID) and classical synthetic or biological disease-modifying antirheumatic (cs/bDMARD) have been employed in the treatment of chronic recurrent multifocal osteomyelitis (CRMO) non-bacterial (CNO). 1, 2 This one is a rare bone childhood illness none guidelines carried out till present. 3 Objectives: To asses which schedule CRMO had best response rates try to expose recommendation. Methods: A systematic literature review was made using Medline, Embase, Cochrane library Web Science databases. The search strategy focused on synonyms CRMO. prevalence meta-analysis performed evaluate each response. Stata 15.1 used perform statistical analysis. Results: identified 1883 articles, 43 were finally selected. Complete rate reached with NSAIDs acceptable [50% (CI95% 40-60)]. Lower by GC [44% 25-63)] csDMARD [38% 28-48)]. complete bDMARD BP treatments [69% 56-82) 73% 62-84), respectively]. Conclusion: supports, taking into account its remission risk-benefit profile, as potential first-line agents treatment. higher rates, turning helpful alternatives. There not any driving patients, but this analysis could help select suitable agent for patient. Decision-making should be individualized. References: [1]Wipff J, Costantino F, Lemelle I, et al . large national cohort French patients osteitis. Arthritis & Rheumatol. 2014;67(4):1128-1137. [2]Zhao Y, Wu E Oliver M S, al. Consensus plans nonbacterial osteomielitis refractory nonsteroideal and/or active spinal lesions. Care Res. 2018;70(8):1228-1237. [3]Menashe SJ, Aboughalia H, Zhao many faces pediatric (CRMO): practical location- case-based approach differenciate from mimics. J Magn Reson Imaging. 2020;e27299. Disclosure Interests: None declared